The van Gemmeren
Research Lab
Publications
66) Transition Metal-Catalyzed Direct C(sp3)–H Functionalization Reactions of Aliphatic Carboxylic Acids
S. Mal, M. van Gemmeren
Chem. Rev. 2026, 126, 4900-4944.
65) Ökofenac – A more biodegradable alternative to topical diclofenac?
C. Woitaske-Proske, M. Schütt, A. Müller, B. Raupers, A. Beck, E. Achterberg, S. Reichl, P. M. Jordan, O. Werz, P. Dahlke, J. Bußmann, F. Jurk, M. van Gemmeren, C. Peifer
Sustain. Chem. Pharm. 2026, 51, 102413.
64) Dual Ligand-Enabled Nondirected C‒H Olefination of (Hetero)Arenes for the Synthesis of Clickable Derivatives
T. Braga, M. Hergert, M. van Gemmeren
Chem. Eur. J. 2026, 32, e00028.
63) Palladium(II)-Catalyzed Nondirected C(sp2)–H Alkoxycarbonylation of Arenes
S. Kaltenberger, J. Meinshausen, J. Dey, C. Sánchez-González, M. van Gemmeren
JACS Au 2025, 5, 6343.
62) Elucidating Ligand-Dependent Selectivities in Pd-Catalyzed C–H Activations
F. Deufel, M. Ravi, M. van Gemmeren
Angew. Chem. Int. Ed. 2025, 64, e202507500.
62) Sterically Controlled C(sp2)-H Carboxylation and Formylation: A Complementary Strategy to SEAr Approaches
R de Jesus,+ J. Dey,+ E. Chakraborty, M. van Gemmeren
(+ = equal contribution)
Org. Lett. 2025, 27, 10849.
Amongst the most accessed publications in
Org. Lett. in October 2025
61) Synthesis of γ-Alkylidene Lactones via Molecular Stitching of Carboxylic Acids and Olefins
E. Crnovrsanin,+ S. Mal,+ M. van Gemmeren
(+ = equal contribution)
Chem. Sci. 2025, 16, 14678-14583.
60) Mild and Efficient Synthesis of Sulfonyl Fluorides from Sulfonamides Enabled by Diethylaminosulfur Trifluoride
F. Jurk, M. van Gemmeren
Synlett 2025, 36, 3117-3120.
F. Anum, C. Assaf, F. H. Mohamad, M. Anikeeva, A. Brahms, J. Dey, S. Kaltenberger, E. Beitz, L. Welz, V. Annis, M. van Gemmeren, S. Duckett, J.-B. Hövener, A. N. Pravdivtsev
NMR in Biomed. 2025, 38, e70121.
E. Akin, E. Sehit, N. S. Moldovean‐Cioroianu, S. Tavaragondi, S. Slenczka, R. Süssmuth, F. Jurk, M. van Gemmeren, Z. Altintas
Adv. Healthcare Mat. 2025, 14, 2502043.
57) Direct Pd-Catalyzed β-C(sp3)–H Hydroxylation of Aliphatic Carboxylic Acids
S. Mal,+ T. Xu,+ M. van Gemmeren
(+ = equal contribution)
Org. Lett. 2025, 27, 6551-6556.
Amongst the most accessed publications in
Org. Lett. in June 2025 and most accessed publications of the year in Org. Lett.
56) The Direct Pd-Catalyzed γ-Lactonization of Aliphatic Carboxylic Acids
T. Xu,+ S. Mal,+ M. van Gemmeren
(+ = equal contribution)
ACS Catal. 2025, 15, 2735-2741.
Amongst the most accessed publications in
ACS Catal. in February 2025.
55) On the Importance of Data – Introducing Perspectives as New Manuscript Type to Synlett
R. Martin*, M. van Gemmeren*, D. Maiti*
Synlett 2025, 36, 322-324.
54) Deuteration of Arenes via Pd-Catalyzed C–H Activation: A Lesson in Nondirected C–H Activation, Isotopic Labeling, and NMR Characterization
F. Deufel, M. van Gemmeren
J. Chem. Educ. 2024, 101, 3410-3417.
53) Pd-catalysed direct β-C(sp3 )–H fluorination of aliphatic carboxylic acids
S. Mal, F. Jurk, K. Hiesinger, M. van Gemmeren
Nat. Synth. 2024, 3, 1292-1298.
Press release: https://www.uni-kiel.de/en/details/news/104-carbonsaeure
52) Palladium(II)-Catalyzed Nondirected Late-Stage C(sp2)–H Deuteration of Heteroarenes Enabled Through a Multi-Substrate Screening Approach
J. Dey,+ S. Kaltenberger,+ M. van Gemmeren
(+ = equal contribution)
Angew. Chem. Int. Ed. 2024, 63, e202404421.
51) Late-Stage C–H Deuteration of Organic Compounds via Ligand-Enabled Palladium-Catalyzed Hydrogen Isotope Exchange
J. Dey, M. van Gemmeren
Synlett 2024, 35, 2191-2200.
50) Controlling Reactivity and Selectivity in the Nondirected C–H Activation of Arenes with Palladium
S. Kaltenberger, M. van Gemmeren
Acc. Chem. Res. 2023, 56, 2459-2472.
Amongst the most accessed publications in
Acc. Chem. Res. in September 2023.
49) Preparative Scale Applications of C–H Activation in Medicinal Chemistry
R. de Jesus, K. Hiesinger, M. van Gemmeren
Angew. Chem. Int. Ed. 2023, 62, e202306659.
Amongst the most accessed publications in the Angew. Chem. Int. Ed. in June 2023
Highlighted as item of interest by
Organic Process Research & Development
48) Sterically controlled isodesmic late-stage C–H iodination of arenes
M. Farizyan, R. de Jesus,+ J. Dey,+ M. van Gemmeren (+ = equal contribution)
Chem. Sci. 2023, 16, 4357-4362.
47) Charge-controlled Pd catalysis enables the meta-C–H activation and olefination of arenes
A. Mondal, M. Diaz-Ruiz,+ F. Deufel,+ F. Maseras,* M. van Gemmeren* (+ = equal contribution)
Chem. 2023, 9, 1004-1016.
Press Release: https://t.co/RV819gTG4y
Highlighted in Nachrichten der Chemie, April 2023
Highlighted by Chem: DOI: j.chempr.2023.03.013
46) A Modular Olefination of Aldehydes with Thiols as Coupling Partners
S. Bognar, M. van Gemmeren
Chem. Eur. J. 2023, 29, e202203512.
45) Silver-Free C–H Activation: Strategic Approaches towards Realizing the Full Potential of C–H Activation in Sustainable Organic Synthesis
A. Mondal, M. van Gemmeren
Angew. Chem. Int. Ed. 2022, 61, e202210825.
44) Palladium-Catalyzed Nondirected Late-Stage C–H Deuteration of Arenes
M. Farizyan,+ A. Mondal,+ S. Mal,# F. Deufel,# M. van Gemmeren (+/# = equal contribution)
J. Am. Chem. Soc. 2021, 143, 16370–16376.
Highlighted by ChemistryViews!
Amongst the most read articles in the Journal of the American Chemical Society in October 2021.
Amongst the most cited articles in the Journal of the American Chemical Society published in 2020/2021.
43) Late-Stage β-C(sp3)–H Deuteration of Carboxylic Acids
A. Uttry, S. Mal, M. van Gemmeren
J. Am. Chem. Soc. 2021, 143, 10895-10901.
Amongst the most cited articles in the Journal of the American Chemical Society published in 2020/2021.
42) Mechanism of the Arene-Limited Nondirected C–H Activation of Arenes with Palladium
P. Wedi,+ M. Farizyan,+ K. Bergander, C. Mück-Lichtenfeld,* M. van Gemmeren (+ = equal cont.)
Angew. Chem. Int. Ed. 2021, 60, 15641-15649.
Hot Paper!
Amongst the most read articles in the Angewante Chemie International Edition in June 2021.
41) Dual Ligand-Enabled Late-Stage Fujiwara-Moritani Reactions
C. Santiago, H. Chen, A. Mondal, M. van Gemmeren
Synlett 2022, 33, 357-360.
Amongst the most cited Synlett articles published in 2021/2022
40) Direct Synthesis of Unsymmetrical Dithioacetals
S. Bognar, M. van Gemmeren
39) Catalyst Controlled Regiodivergent C‐H Alkynylation of Thiophenes
A. Mondal, M. van Gemmeren
Angew. Chem. Int. Ed. 2021, 60, 742-746.
38) How and Why Crowd Reviewing Works
M. van Gemmeren*, B. List*
Synlett 2021, 32, 885-891.
Cover picture!
37) Non-Directed Distal C(sp2)-H Functionalization of Arenes
A. Mondal,+ P. Wedi,+ M. van Gemmeren
(+ = equal contribution)
in Remote C–H Bond Functionalization: Methods and Strategies in Organic Synthesis (Ed. D. Maiti, S. Guin). Wiley-VCH, 2021, ISBN: 978-3-527-34667-7
36) Electrochemical Methods for Pd‐catalyzed C–H Functionalization
J. E. Erchinger, M. van Gemmeren
Asian J. Org. Chem. 2021, 10, 50-60.
Amongst the most read articles in the Asian Jouranl of Organic Chemistry between July 2020 and June 2021.
2011-2020
35) F. Ghiringhelli, A. Uttry, K. K. Ghosh, M. van Gemmeren, Direct β‐ and γ‐C(sp3)–H Alkynylation of Free Carboxylic Acids, Angew. Chem. Int. Ed. 2020, 59, 23127-23131. DOI: 10.1002/anie.202010784.
34) H. Chen,+ M. Farizyan,+ M. van Gemmeren, Regioselective Olefination of 3‐Substituted Five‐membered Heteroarenes, Eur. J. Org. Chem. 2020, 6318-6327. DOI: 10.1002/ejoc.202000659 (+ = equal contribution). Very Important Paper! This Minireview is part of the Special Collection: ADUC Prize Winners.
33) H. Chen,+ M. Farizyan,+ F. Ghiringhelli, M. van Gemmeren, Sterically Controlled C−H Olefination of Heteroarenes, Angew. Chem. Int. Ed. 2020, 59, 12213-12220. DOI: 10.1002/anie.202004521 (+ = equal contribution). Highlighted in Synfacts: 10.1055/s-0040-1705846
32) K. K. Ghosh,+ A. Uttry,+ A. Mondal, F. Ghiringhelli, P. Wedi, M. van Gemmeren, Ligand‐Enabled γ‐C(sp3)−H Olefination of Free Carboxylic Acids, Angew. Chem. Int. Ed. 2020, 59, 12848-12852. DOI: 10.1002/anie.202002362 (+ = equal contribution).
31) A. Uttry, M. van Gemmeren, Direct C(sp3)–H Activation of Carboxylic Acids, Synthesis 2020, 52, 479-488. DOI: 10.1055/s-0039-1690720
30) A. Mondal, H.Chen,+ L. Flämig,+ P. Wedi,+ M. van Gemmeren, Sterically Controlled Late-Stage C–H Alkynylation of Arenes, J. Am. Chem. Soc. 2019, 141, 18662-18667. DOI: 10.1021/jacs.9b10868 (+ = equal contribution). Amongst the most read articles in The Journal of the American Chemical Society in November 2019. Highlighted in Synfacts: 10.1055/s-0039-1691478
29) K. K. Ghosh,+ A. Uttry,+ A. Koldemir,# M. Ong,# M. van Gemmeren, Direct β-C(sp3)–H Acetoxylation of Aliphatic Carboxylic Acids, Org. Lett. 2019, 21, 7154-7157. DOI: 10.1021/acs.orglett.9b02741 (+/# = equal contribution). Highlighted in Synfacts: 10.1055/s-0039-1691030
28) H. Chen, A. Mondal, P. Wedi, M. van Gemmeren, Dual Ligand-Enabled Nondirected C–H Cyanation of Arenes, ACS Catal. 2019, 9, 1979–1984. DOI: 10.1021/acscatal.8b04639
27) F. Ghiringhelli, L. Nattmann, S. Bognar, M. van Gemmeren, The Direct Conversion of α-Hydroxyketones to Alkynes, J. Org. Chem. 2019, 84, 983-993. DOI: 10.1021/acs.joc.8b02941
26) P. Wedi, M. van Gemmeren, The Arene-Limited Nondirected C–H Activation of Arenes, Angew. Chem. Int. Ed. 2018, 57, 13016-13027. DOI: 10.1002/anie.201804727. Amongst the most accessed articles of the Angewandte Chemie in September 2018.
25) A. Uttry, M. van Gemmeren, The Direct Pd-Catalyzed β-C(sp3)–H Activation of Carboxylic Acids, Synlett 2018, 29, 1937-1943.
24) H. Chen,+ P. Wedi,+ T. Meyer, G. Tavakoli, M. van Gemmeren, Dual Ligand-Enabled Non-Directed C–H Olefination of Arenes, Angew. Chem. Int. Ed. 2018, 57, 2497-2501. DOI: 10.1002/anie.201712235 (+ = equal contribution). Amongst the most accessed articles of the Angewandte Chemie in January 2018 and in the year 2018!
23) K. K. Ghosh, M. van Gemmeren, Pd-Catalyzed β-C(sp3)–H Arylation of Propionic Acid and Related Aliphatic Acids, Chem. Eur. J. 2017, 23. 17697-17770. DOI: 10.1002/chem.201705449
22) M. van Gemmeren,+ M. Börjesson,+ A. Tortajada,+ S.-Z. Sun,+ K. Okura, R. Martin, Switchable Site-Selective Catalytic Carboxylation of Allylic Alcohols with CO2, Angew. Chem. Int. Ed. 2017, 56, 6558-6562 (+ = equal contribution).
21) D. Höfler, M. van Gemmeren, P. Wedemann, K. Kaupmees, I. Leito, M. Leutzsch, J. B. Lingau, B. List, 1,1,3,3-Tetratriflylpropene (TTP): A Strong, Allylic C-H Acid for Brønsted and Lewis Acid Catalysis, Angew. Chem. Int. Ed. 2017, 56, 1411-1415.
20) C. Zarate,+ M. van Gemmeren,+ R. J. Sommerville, R. Martin, Adv. Organomet. Chem. 2016, 66, 143-222.
19) Zhang, H. Y. Bae, J. Guin, C. Rabalakos, M. van Gemmeren, M. Leutzsch, M. Klussmann, B. List, Nat. Commun. 2016, 7:12478.
18) F. Juliá-Hernández, M. Gaydou, E. Serrano, M. van Gemmeren, R. Martin, Top. Curr. Chem. 2016, 374, 1-38.
17) T. Gatzenmeier,+ M. van Gemmeren+ Y. Xie, D. Höfler, M. Leutzsch, B. List, Science 2016, 351, 949-952.
16) T. James, M. van Gemmeren, B. List, Chem. Rev. 2015, 115, 9388-9409.
15) J. Guin, Q. Wang, M. van Gemmeren, B. List, Angew. Chem. Int. Ed. 2015, 54, 355-358.
14) K. Hyodo, S. Gandhi, M. van Gemmeren, B. List, Synlett 2015, 1093-1095.
13) Q. Wang, M. van Gemmeren, B. List, Angew. Chem. Int. Ed. 2014, 53, 13592-13595.
12) L. Ratjen,+ M. van Gemmeren+ F. Pesciaioli, B. List, Angew. Chem. Int. Ed. 2014, 53, 8765-8769.
11) M. van Gemmeren, F. Lay, B. List, Aldrichimica Acta 2014, 47, 3-13.
10) A. Martínez, M. van Gemmeren, B. List, Synlett 2014, 961-964.
9) A. Martínez, K. Zumbansen, A. Döring, M. van Gemmeren, B. List, Synlett 2014, 932-934.
8) B. List, I. Čorić, O. O. Grygorenko, P. S. J. Kaib, I. Komarov, A. Lee, M. Leutzsch, S. C. Pan, A. V. Tymtsunik, and M. van Gemmeren, Angew. Chem. Int. Ed. 2014, 53, 282-285.
7) Q. Wang, M. Leutzsch, M. van Gemmeren, B. List, J. Am. Chem. Soc. 2013, 135, 15334-15337.
6) O. Lifchits, M. Mahlau, C. M. Reisinger, A. Lee, C. Farès, I. Polyak, G. Gopakumar, W. Thiel, B. List, J. Am. Chem. Soc. 2013, 135, 6677-6693.
5) M. Mahlau, B. List, Angew. Chem. Int. Ed. 2013, 52, 518-533.
4) M. Mahlau, P. García-García, B. List, Chem. Eur. J. 2012, 18, 16283-16287.
3) M. Mahlau, B. List, Asymmetric Counteranion‐Directed Catalysis (ACDC), in Asymmetric Synthesis II: More Methods and Applications (Ed. M. Christmann, S. Bräse), Wiley-VCH, Weinheim, 2012, P. 79-84.
2) M. Mahlau, B. List, Isr. J. Chem. 2012, 52, 630-638.
1) M. Mahlau, R. A. Fernandes, R. Brückner, Eur. J. Org. Chem. 2011, 4765-4772.